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However, in pathological states associated with tinnitus and neurodegeneration, this translocation is impaired or the binding affinity of Nrf2 to ARE is diminished, resulting in insufficient upregulation of antioxidant enzymes (Scuto et al., 2020

Patients should verify that their compounding pharmacy is licensed and follows current Good Manufacturing Practice

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Normally, -LA is found in small quantities in body tissues and is bound to an enzyme complex that limits its function as an antioxidant